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  • Platelet Rich Plasma (PRP)

    Platelet Rich Plasma Therapy (PRP), an innovative and increasingly popular cellular treatment in Regenerative Orthopedics, promotes and accelerates the body's natural healing process for soft tissue injuries and osteoarthritis. It is one of the first orthobiologic therapies for treatment of orthopedic conditions, using your own blood cells in concentrated doses to stimulate the natural healing process. PRP is also effective in reducing joint inflammation to help reverse the degenerative effects of osteoarthritis.

    How does PRP therapy work?

    Blood contains amazing healing power with many types of cells working to maintain the health of the entire body. Plasma, the liquid portion of blood, acts primarily as a transport medium for blood cells, nutrients, and metabolic waste products, contributing to the physiological stability of the body. Plasma is mostly water, but also contains proteins that reduce pain and inflammation. Blood cells called macrophages remove damaged tissue to clean the injured area in preparation for the healing process.

    Another cell in the blood, platelets, were once thought to only function in formation of blood clots. They are one of the first cells to rush to an injury to stop bleeding. Research has since discovered that platelets also contain growth factors, such as alpha-granules, and tissue building proteins that are central to tissue repair. Platelets stimulate release of localized stem cells through a process called "signaling." Mesenchymal stem cells then direct the complex procedure of cellular healing.  Read more about how our body creates new tissue. PRP condenses platelet cells to magnify their healing capacity, accelerating and enhancing the healing process.

    If our bodies heal themselves, why is PRP sometimes needed?

    In the musculoskeletal system, collagenous tissue, such as tendons, ligaments and cartilage, have extremely poor blood supply, which gives them their whitish appearance. Because of the important role blood plays in the the process of healing, these tissues heal slowly and often incompletely.

    PRP therapy helps the body's natural healing process by injecting large quantities of platelets to the site of injury. The platelets stimulate activation of localized stem cells and promote a healing response in surrounding tissue. They promote a matrix formation of soft tissue where collagen molecules deposit to repair damaged tissue. Cartilage, ligaments, and tendons heal to become more firm and more resilient. Growth factors contained in the platelets and plasma stimulate blood flow. The production of new blood vessels is increased, continuing to feed and maintain tissue.

    PRP video

    If you have injured your knee or if normal wear and tear has caused degeneration of your joint, stem cell therapy may help. It uses your own bone marrow to help repair knee damage. It may help you avoid surgery.

    Regenerative Orthopedics

    Common applications

    Numerous conditions can be considered for PRP. Based on current research and clinical experience, moderate to severe cases of osteoarthritis and tendon injuries show promising results.
    •    Knee Pain – Osteoarthritis, Meniscus Tears, Chondromalacia Patella, Tendon Injuries, Ligament sprains or tears.
    •    Hip Pain – Osteoarthritis, Hip Labrum Tears, SI Joint Arthritis, Gluteal tendon tears, Iliotibial Band (ITB) Syndrome
    •    Shoulder – Osteoarthritis, Rotator Cuff Tendinitis, Tendinopathy, or Tears, Labrum Tear, Bicipital Tendinitis
    •    Elbow Pain – Lateral Epicondylitis (Tennis Elbow), Medial Epicondylitis (Golfers Elbow), Osteoarthritis
    •    Wrist/Hand Pain – Osteoarthritis, DeQuervain’s Tenosynovitis
    •    Ankle & Foot Pain – Achilles Tendinitis or Partial Tears, Plantar Fasciitis Ankle sprains/ligament injury

    Leader in orthobiologic treatment for musculoskeletal conditions

    Dr. Minotti began performing Orthobiologic Therapy in 2007 and has treated hundreds of patients with amazing success. 86% of his patients have found significant relief from pain and restoration of musculoskeletal function. The use of orthobiologics in treatment of musculoskeletal conditions is an emerging field with evidence of its success accelerating rapidly. Research examining the biological mechanisms of cellular health and tissue regeneration is extensive, particularly the behavior of platelets, stem cells, and natural growth factors in the blood.

    Dr. Minotti is Board Certified and specialty trained in Neuromusculoskeletal Medicine and Osteopathic Manipulative Medicine by the American Board of Neuromusculoskeletal Medicine. He holds numerous certificates from the Interventional Orthopedics Foundation and is completing Interventional and Regenerative Orthopedic Medicine Certification (IROM-C) from the American Academy of Orthopedic Medicine and the Orthohealing Method. Dr. Minotti also serves as an adjunct professor at University of North Texas Health Science Center. Read more.

    Many scientists believe the concept of intrinsic healing is a new frontier. Medicine is changing. The wonders of the human body and its ability to balance and heal itself are at the center of this medical renaissance.


    PRP: Procedure SnapshotPRP: Procedure Snapshot

    The patient's blood is drawn and spun in a centrifuge to isolate the platelets and their associated growth factors. This process increases the level of platelets from a concentration of 6% to 94%. Concentrated platelets are added to the patient's plasma. Plasma contains a variety of proteins that are essential to connective tissue healing. Using ultrasound guidance, this preparation is then injected into the damaged area, stimulating release of stem cells that accelerate and enhance new cell growth. Collagen molecules are subsequently deposited on the damaged tissue, resulting in tissue regeneration and restored blood flow.

    Because the injected solution is prepared from the your own blood using aseptic technique, your body has no risk of rejection or exposure to blood-borne diseases.

    The procedure takes about 1 hour and the patient can return home the same day. Healing from the procedure takes about 1 week. Healing of injured tissue depends on the severity of the injury and healing tendencies of the individual. Many patients feel pain relief within weeks of the procedure. Follow up injections 6 months later can boost the initial treatment for increased healing and pain relief.

    Adverse reactions associated with PRP injections are remote and usually of minor severity-most commonly, injection site pain and infection.


    Scientific advances in the understanding of how the body actually heals through tissue regeneration, combined with rapid developments in stem cell biology, have truly created a renaissance in medical treatment. Stem cells, like other medical products that are intended to treat, cure or prevent disease, require U.S. Food and Drug Administration (FDA) approval before they can be marketed. At this time, only cells harvested from the patient’s own body and that are only minimally manipulated have been approved by the FDA.

    Additionally, devices that allow physicians to minimally manipulate blood, bone marrow and adipose tissue for the treatment of orthopedic conditions also require FDA approval. NTXMSK recognizes and welcomes the FDA’s important role in assuring patient safety. All of our treatment protocols are compliant with the published FDA guidelines regarding the use of human cells, tissues, and cellular or tissue-based products.