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  • Platelet Rich Plasma (PRP)

    Platelet Rich Plasma Therapy (PRP), an innovative and increasingly popular cellular treatment in Regenerative Orthopedics, promotes and accelerates the body's natural healing process for soft tissue injuries and osteoarthritis. It is one of the first orthobiologic therapies for treatment of orthopedic conditions, using your own blood cells in concentrated doses to stimulate the natural healing process. PRP is also effective in reducing joint inflammation to help reverse the degenerative effects of osteoarthritis.

    How does PRP therapy work?

    Blood contains amazing healing power with many types of cells working to maintain the health of the entire body. Plasma, the liquid portion of blood, acts primarily as a transport medium for blood cells, nutrients, and metabolic waste products, contributing to the physiological stability of the body. Plasma is mostly water, but also contains proteins that reduce pain and inflammation. Blood cells called macrophages remove damaged tissue to clean the injured area in preparation for the healing process.

    Another cell in the blood, platelets, were once thought to only function in formation of blood clots. They are one of the first cells to rush to an injury to stop bleeding. Research has since discovered that platelets also contain growth factors, such as alpha-granules, and tissue building proteins that are central to tissue repair. Platelets stimulate release of localized stem cells through a process called "signaling." Mesenchymal stem cells then direct the complex procedure of cellular healing. Read more about how our body creates new tissue. PRP condenses platelet cells to magnify their healing capacity, accelerating and enhancing the healing process.

    If our bodies heal themselves, why is PRP sometimes needed?

    In the musculoskeletal system, collagenous tissue, such as tendons, ligaments and cartilage, have extremely poor blood supply, which gives them their whitish appearance. Because of the important role blood plays in the the process of healing, these tissues heal slowly and often incompletely.

    PRP therapy helps the body's natural healing process by injecting large quantities of platelets to the site of injury. The platelets stimulate activation of localized stem cells and promote a healing response in surrounding tissue. They promote a matrix formation of soft tissue where collagen molecules deposit to repair damaged tissue. Cartilage, ligaments, and tendons heal to become more firm and more resilient. Growth factors contained in the platelets and plasma stimulate blood flow. The production of new blood vessels is increased, continuing to feed and maintain tissue.

    Regenexx is a world-wide network of select, highly skilled physicians who are specially trained in interventional procedures for orthopedic conditions. Regenexx provides the world's most advanced, research-driven, regenerative orthopedic procedures in North America, Europe, the Middle East, Asia and Australia. Specializing in advanced non-surgical procedures for joint Injuries, osteoarthritis, and other orthopedic conditions, Dr. Minotti brings these procedures to you!

    PRP video

    If you have injured your knee or if normal wear and tear has caused degeneration of your joint, stem cell therapy may help. It uses your own bone marrow to help repair knee damage. It may help you avoid surgery.

    To determine if Regenerative Orthopedics will be helpful for you, please tell us about your condition.

    Common applications

    Numerous conditions can be considered for PRP. Based on current research and clinical experience, moderate to severe cases of osteoarthritis and tendon injuries show promising results.
    • Knee Pain – Osteoarthritis, Meniscus Tears, Chondromalacia Patella, Tendon Injuries, Ligament sprains or tears.
    • Hip Pain – Osteoarthritis, Hip Labrum Tears, SI Joint Arthritis, Gluteal tendon tears, Iliotibial Band (ITB) Syndrome
    • Shoulder – Osteoarthritis, Rotator Cuff Tendinitis, Tendinopathy, or Tears, Labrum Tear, Bicipital Tendinitis
    • Elbow Pain – Lateral Epicondylitis (Tennis Elbow), Medial Epicondylitis (Golfers Elbow), Osteoarthritis
    • Wrist/Hand Pain – Osteoarthritis, DeQuervain’s Tenosynovitis
    • Ankle & Foot Pain – Achilles Tendinitis or Partial Tears, Plantar Fasciitis Ankle sprains/ligament injury


    Patient Reviews

    • Excellent experience! The staff and Dr. Minotti are all friendly, helpful, and knowledgeable. I received PRP Therapy in both knees and have noticed significant improvement in daily movement and functionality. Highly recommend. Charity C

    • I’m writing this review on behalf of my mom who is a patient here. She raves about Dr. Philip. She had gone in for frozen shoulder and back pain, and is currently undergoing OMT (osteopathic manipulative therapy). After a few treatments, she experienced significant improvements, and she attributes them to “Dr. Philips magic hands”. Not only is he kind and intelligent, but it is very evident that he genuinely cares about his patients. Bottom line: I would highly recommend Dr. R Philip. Maryam

    • Friendly staff,schedule flexibility is good. The doctors I have seen so far are nice, knowledgeable and helpful in helping you making decision. Their services and treatments are good. Frederick M P

    • Dr. Philip’s work in OMT has not only helped to relieve neck pain I had dealt with for years, it is obvious he truly cares for the well-being of his patients through his careful listening and willingness to offer recommendations and guidance. Jennifer F

    • No more pain, 10000% recommend Dr. Philips. David B

    • Dr. Philip has been awesome in helping me heal through several different joint issues. He is very kind and has a great bedside manner as well as being thorough and knowing his stuff! Highly recommend! Kim L

    • Dr Philip and then NTXMSK team are awesome. From the initial evaluation and follow up my foot pain was resolved. A therapeutic approach that works. Joseph DAmore

    • Significant difference in my strength after the treatment!! I wasn't sure how much difference the prp could make, but I thought worth a try. I would have been pleased with half the improvement I received. I'm amazed at the difference 8 weeks after treatment. Dr Minotti is more like a super smart brother, that answers questions in a friendly manner, the way only experts can! Michele I

    • I am so grateful for Dr. Minotti and his staff! After 10 years of dealing with a painful musculoskeletal injury, Dr. Minotti‘s prolotherapy has made an incredible difference in my life. His skill in how he administers treatment is wonderful — gentle, effective, and always making it as comfortable as possible. Thank you, NTXMSK! Anna F

    • I have had shoulder pain for 10+ years and was recently told that I’d need a complete shoulder replacement. A friend recommended that I see Dr Minotti before doing any surgery. Thankfully, I did. Dr Minotti did PRP on my right shoulder 8 weeks ago. The whole thing only took about an hour and was relatively painless(a few injections). My shoulder feels better than it has in 10 years. I still have a small amount of pain but NOTHING like before the PRP. He also said that it will continue to get better for another month or so. I couldn’t be happier with the results and I would HIGHLY recommend anyone see him if you’re having joint pain. Dr Minotti is a lifesaver for me! Rick T

    • As many people know, very significant osteoarthritis causes great knee pain...

      As many people know, very significant osteoarthritis causes great knee pain and - wanting to avoid surgery - in late August, 2020, I received a Platelet Rich Plasma (PRP) treatment given by Dr. Minotti. Dr. Minotti is an extremely gifted D.O. who uses ultra sound to precisely administer the PRP shots into pivotal places in each knee. I experienced only minor discomfort for 48 hours and on the third day, I was already experiencing relief when I walked. Now, five weeks later, I walk with ease and my expectation is that this knee comfort will continue to grow for another few weeks AND it will also slow down the progression of the osteoarthritis. I am so pleased with the results, I am planning to have another treatment within six months to build up my knees even more. This PRP procedure has exceeded my very best expectations and I highly recommend it and Dr. Minotti to anyone who has such a need.

    • Arthritis in hands and stress fracture foot

      Arthritis in my finger joints was getting worse and simple tasks caused a lot of pain. Also was experiencing loss of strengthin hands. Dr Minotti was able to walk me through various options and help me make an informed decision on what treatment plan was best for me. I chose to go with PRP and although the treatments were uncomfortable, they worked! I had my first treatment on the most damaged joints and all but a couple were now pain free. I opted to do a second treatment and now everything is pain free. My joints are flexible and not aching. I can sew and do all my projects without any pain. I also hada stress fracture in my foot that was not healing with conventional methods. Dr. Minotti walked me through the PRP process and was able to get me back on my feet with just one treatment. I highly recommend him and his team. They always make me feel welcome and make sure I understand the whole process. Follow up was great too. Thanks Dr. Minotti! Beverly S

    • Dr. Minotti is on the cutting edge.

      This PRP procedure has been excellent and definitely worth while. It has greatly helped my osteoarthritis and keeps my knees much more flexible. My quality of life has greatly improved seeing Dr. Minotti. Patricia O

    • I have been pleased with the outcome of my treatment.

      I have had degenerative pain in my thumbs & lower back. I was treating the back pain with chiropractic treatments but not experiencing a more permanent outcome With PRP treatments I am getting more relief each time I have received a treatment. I am satisfied with the progress being made and plan to continue treatments further. Nancy P.

    • Dr. Minotti and Natasha are an awesome team

      I had the prp procedure done on my cervical and lumbar areas well over 7 months ago and haven't experienced any pain from both areas.Dr.Minotti is so down to earth. He's so cool, and very educated and knowledgeable. I'm so comfortable whenever see him and Natasha, because they make you feel at ease. Wendy M

    • PRP improved my shoulder and low back/hip pain

      I had struggled with pain in my shoulder as well as low back, hip/sacral area for several years before meeting Dr. Minotti.I had spent quite a bit of time, enegy and financial resources on visits with other doctors and chiropractors before meeting the team at North Texas Musculoskeletal. I consider myself to be a pretty active inliidual and was very disappointed that I was having to refrain from many types of activities that I enjoyed because the pain was so limiting. It even got to a point where picking up my infant was nearly impossible at times. After treatment with PRP, I was able to slowly ease back into normal exercises and activities that I had missed. I have such high regards for Dr. Minotti and recommend PRP to many that are suffering from pain and would like a more natural approach where our own body can do as it was designed and help heal itself. Charity B.

    • I felt like I was well informed beforehand and post procedure was great.

      Dr. MInotti and his staff are very good communicators , explained things and didn't try to pressure me into decision. Very helpful and friendly. Charlotte B

    • Dr Minotti answered my questions in a way that easy to understand. The procedure went exactly as ...

      Dr Minotti answered my questions in a way that easy to understand. The procedure went exactly as described and the results are excellent. My knee is pain free for the first time in a long time. Lance G

    • PRP is working

      My injection is slowly making my life much better. Pain is considerably less Terry H

    • Outstanding!

      After multiple consultations with several different providers, I heard through a colleague about NTMSK and Dr. Minotti. After my initial visit, I'm sure glad I was referred to NTMSK! Before leaving the office, I knew I was in the right place! I've been under the care of Dr. Minotti for the last 8 months and always look forward to the follow up visits. My shoulder is much better than when I initially saw Dr. Minotti in the latter part of 2019. Thank you NTMSK and Dr. Minotti! Rob F

    • excellent

      My knee pain is almost gone and after 7 months I have noticed increased strength and range of motion when doing yoga. I am grateful for Doctor Minotti& staff. Deborah Y

    • PRP for Achilles Tendinitis

      I cannot say enough positive things about this provider. After nearly 16 years of chronic pain due to a stress fracture that rubbed on my Achilles tendon, I finally found relief! ONE treatment of Platelet Rich Plasma solved this issue. Regenerative Orthopedics should be the best practice standard!! Thank you, Dr. Minotti! Teresa C

    • Always providing great counsel

      Dr. Minotti's bedside manner is always exceptional. He listens well, offers great advice, and is very comprehensive. I trust him and will continue to seek out his medical opinions on my health. I can't recommend him enough. Joel S

    • Huge success treating torn rotator cuff with PRP

      Dr. Minotti is very caring and knowledgeable. We're blessed to have a leader in this field in the DFW metroplex! I'm so happy to be out of pain, back to full strength and to have avoided surgery that would have been costly and would have had long downtime. His staff is great too--no bruising after my blood draw which I greatly appreciated. I highly recommend Dr. Minotti. Rachel L

    • Life changing!!

      I was a chiropractor junkie. The more I went the more I needed it. I have spondylolisthesis meaning L5 has slipped forward causing me pain and discomfort in my low back and hips. After the first treatment I was 80 percent better and able to resume normal activities. I decided to have a second treatment because I wanted to get to start working out without aggravating my low back. This has truly been life changing and I recommend it to everyone. I have not been to a chiropractor in over 9 month!! Sandra L

    • I always walked out with a smile on my face after each appointment

      Dr. Minotti is very thorough, and takes time to listen and is always conservative with his treatment recommendations. I have had muscle manipulation treatments and PRP on my shoulder and big toe on my right foot. I have been in much better health since I started being treated by Dr.Minotti, no more chiropractor for me! I have been seeing Dr.Minotti over 4 years. He's the best!!!! BE

    • Myriad of problems in the shoulder. Torn rotator cuff. Arthritis. Cysts.

      Myriad of problems in the shoulder. Torn rotator cuff. Arthritis. Cysts. Being the dutiful American health care prisoner , I went to my primary care physician. Naturally, surgery was recommended. However, it ain't what you know, it's who you know, and I eventually ended up on Dr. Minotti's doorstep. After a lifetime of bad decisions, finally one I can safely say was one of the best. Just a good man. Knows his business. I can't say that PRP is a picnic (actually it's only mildly annoying. More weird than painful) but it took half an hour, no scalpels, no cuts. And so much more affordable than surgery. He said it would take about 8-12 weeks ...and it did. Spot on. I had a second round three months later. It's now three months after that, and I am 100% fully operational. It's like nothing ever happened. Bottom line: go see this guy for your aches and pains and tears and such. Office staff is exceptional. His assistants are amazing (thank you for letting me squeeze the rubber duck). Detailed explanations during the procedure. Wonderful man, wonderful doctor, wonderful results. Bob B

    • Professional staff. Dr Minotti spent a long time and I felt amazing when I left...

      Professional staff. Dr Minotti spent a long time and I felt amazing when I left; hip pain better! I like the natural approach. Highly recommend. Kim R

    • These guys are super! They are some of the few DOs who still practice manipulation. If you’ve not taken advantage of their services, you should try them out. Dr Jay Roop is my Dr and he’s fabulous! A nice gentle touch combined with great training to see quickly what’s out of alignment he needs to focus on. He’s a Dr who listens! He also is a Family Medical qualified Dr who focuses on the manipulation practice since he knows how effective it can be. Judy

    • So happy to have FINALLY found real osteopathic physicians that perform OMT. I receive ongoing treatment from Dr. Cox for numerous skeletal issues and injuries. He is precise, efficient and very, very good. Dr. Minotti has given me PRP procedures for shoulder injuries, including osteoarthritis and bursitis. I have relief for the first time since October of 2016. Would not hesitate to recommend! Teresa

    • They are wonderful! They have helped my daughter so much with numerous soccer injuries, both knee and back. Highly recommend! Leah Leah

    • I felt that I had tried everything, from massage and chiropractic, to acupuncture and even Cervical epidural steroid injection (which were VERY expensive, painful, and even traumatizing); and nothing seemed to work. Then, my Orthopedist told me about Dr. Minotti … WOW! The lessening of pain was amazing and fast – I soon cut back on my medications, and have since eliminated them altogether. The increase in range of motion and mobility, combined with the significant decrease in pain, are phenomenal. I now recommend Dr. Minotti to everyone I know who is suffering from any kind of joint or muscle pain. Jim Mayher

    • I was very IMPRESSED with the treatment I received from Dr. Roop. I limped into his office in pain from an injury the previous night. Upon examination, Dr. Roop knew exactly what I had done and how to treat me. I walked out of his office limp free and within 24 hours I was completely pain free. Debra

    • I drive 90 minutes to see Dr. Minotti. He’s that good.

    • Dr. Minotti is simply the best in the business. His needle technique is unparalleled, and is ALWAYS on the cutting edge with his continuing education. Unlike many "regenerative" or pain clinics around this area, this clinic is not a cash machine or conveyor belt and does NOT price gouge. Front office staff VERY educated, and pleasant as well. Definitely a 5 star rating. Wendy Herman

    • Dr Cox was recommended to me by a friend. I was suffering with very painful sciatica and had tried several different modalities with no relief. I was amazed at how Dr Cox could tell where the pain was with just palpation. The manipulation was very gentle. I was given exercises to do. It started getting better after the first treatment. Unlike chiropractic treatments which require several visits a week for as long as it takes, my visits to Dr Cox were a couple weeks apart. As I got better, the visits were even further apart. My sciatica pain is gone. My husband is now planning a visit to Dr Cox as well. I highly recommend Dr Cox. Sue Carle Estes

    • Dr. Minotti is the absolute BEST. He is compassionate, caring and very professional. He makes sure you are receiving the best care possible. Edna

    • Dr. Minotti was able to provide the care I needed rather than just giving me medicine to relieve pain. He has proven to work at the root issue of my pain with a specific plan at addressing overall wellness. I would recommend Dr. Minotti for any friend or family. James

    • Best experience I have had with any physician. Not only did he listen , but he took steps to positively address my issues.

    • One morning I woke up with a horrible pain in my right shoulder. The pain expanded to include all of my right arm and part of my neck. I noticed I was loosing strength in my right arm as well. I scheduled an appointment with Dr. Roop, and upon my first visit he was able to reduce the pain significantly. After my third visit the pain was totally gone.

    • I have had episodes similar to this one in the past, but I’ve never had the pain dissipate as quickly as with the treatment provided by Dr. Roop. I firmly believe in his knowledge and expertise and whole-heartedly recommend his services for others who are suffering from this type ailment. Monty

    • Dr. Minotti asks straight forward questions and then, intently listens so the patient can answer clearly. He does not dictate a plan of care but develops one with the patient’s input. His compassion is unsurpassed. John

    • The visits are always on time. He is very patient explaining the procedures and ideas on how to improve my health issues. I never feel rushed. I have recommended Dr. Minotti dozens of times. I could not be more pleased with his service.

    • ABSOLUTELY the very best in his field. A God send to me. Dr. Minotti has helped me more than any other physician I have consulted with regarding my pain level.


    Leader in orthobiologic treatment for musculoskeletal conditions


    Dr. Minotti began performing Orthobiologic Therapy in 2007 and has treated hundreds of patients with amazing success. 86% of his patients have found significant relief from pain and restoration of musculoskeletal function.

    Dr. Minotti is specialty trained in Neuromusculoskeletal Medicine. He combines his intensive training in the musculoskeletal system with advanced training in Regenerative Medicine, specifically as applied to orthopedic conditions. He conferences regularly with the world’s leading physicians to provide his patients with the most effective treatments that science has to offer.

    Founder of North Texas Musculoskeletal Medicine in Southlake TX, Dr. Minotti believes that orthobiologic procedures, such as Platelet Rich Plasma (PRP) and Stem Cell Therapy, are a new frontier in medicine, offering treatments that effectively bridge the gap between medications that mask pain and invasive surgery. He has helped thousands of patients find freedom from pain to restore their quality of life. Dr. Minotti is honored to be recognized by his peers with the Top Docs award. He also serves as an adjunct professor at University of North Texas Health Science Center.


    PRP: Procedure SnapshotPRP: Procedure Snapshot

    The patient's blood is drawn and spun in a centrifuge to isolate the platelets and their associated growth factors. This process increases the level of platelets from a concentration of 6% to 94%. Concentrated platelets are added to the patient's plasma. Plasma contains a variety of proteins that are essential to connective tissue healing. Using ultrasound guidance, this preparation is then injected into the damaged area, stimulating release of stem cells that accelerate and enhance new cell growth. Collagen molecules are subsequently deposited on the damaged tissue, resulting in tissue regeneration and restored blood flow.

    Because the injected solution is prepared from the your own blood using aseptic technique, your body has no risk of rejection or exposure to blood-borne diseases.

    The procedure takes about 1 hour and the patient can return home the same day. Healing from the procedure takes about 1 week. Healing of injured tissue depends on the severity of the injury and healing tendencies of the individual. Many patients feel pain relief within weeks of the procedure. Follow up injections 6 months later can boost the initial treatment for increased healing and pain relief.

    Adverse reactions associated with PRP injections are remote and usually of minor severity-most commonly, injection site pain and infection.


    Scientific advances in the understanding of how the body actually heals through tissue regeneration, combined with rapid developments in stem cell biology, have truly created a renaissance in medical treatment. Stem cells, like other medical products that are intended to treat, cure or prevent disease, require U.S. Food and Drug Administration (FDA) approval before they can be marketed. At this time, only cells harvested from the patient’s own body and that are only minimally manipulated have been approved by the FDA.

    Additionally, devices that allow physicians to minimally manipulate blood, bone marrow and adipose tissue for the treatment of orthopedic conditions also require FDA approval. NTXMSK recognizes and welcomes the FDA’s important role in assuring patient safety. All of our treatment protocols are compliant with the published FDA guidelines regarding the use of human cells, tissues, and cellular or tissue-based products.

    We Can Help

    To learn more about what we can do to help with your condition, call our office at 817-416-0970. We will thoroughly diagnose your condition and present you with treatment options. From there we will guide you along your road to recovery.