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Stem Cell Therapy

Bodies heal through tissue regeneration. Damaged cells are replaced by new cells that our body naturally generates. Sufficient nutrients, natural growth factors, and stem cells must be present for regeneration to occur effectively. Collagenous tissue in joints, however, can be slow to heal, and healing is often incomplete. This is largely due to blood flow needed to supply cells necessary for regeneration. The thick, fibrous tissue in joints is great for stability, but inhibits blood flow to supply what the body needs to heal.

Another reason that adequate healing may not occur is that stem cells and nutrients in surrounding tissue may have become depleted due to chronic or severe injury, arthritis, or poor cellular health. When availability of stem cells and necessary healing cells does not keep up with healing demands, the body needs a little help.

Regenerative Orthopedic procedures, such as Bone Marrow Aspirate Concentrate commonly known as Stem Cell Therapy, are often referred to as “orthobiologics.” They use naturally derived proteins, growth factors, and stem cells to stimulate and enhance your body’s healing of muscles, bones, tendons, ligaments, and joints. The quarterback on this team of healing cells is mesenchymal stem cells.

What are stem cells?

The presence of stem cells is key in stimulating the body's natural repair system by inducing the proliferation of cells. Research that examines the biological mechanisms of cellular health and tissue regeneration is extensive, particularly the role of platelets, stem cells and natural growth factors in the blood and bone marrow. Stem cells are present in all of us, acting as a repair system for the body. Mesenchymal stem cells (MSCs) have two primary functions: differentiation into functional cells such as cartilage and coordination of the healing process.

How does Stem Cell Therapy work?

Stem Cell Therapy is a non-invasive treatment designed to help the body repair damaged cells. With increased age or chronic injury, often the optimal amount of stem cells is not available. Injury, arthritis and poor cellular health disrupt the availability of stem cells needed for tissue repair resulting in the body's inability to keep pace with healing requirements. When this demand outpaces the supply, the body needs a little help. The potential to treat conditions, such as osteoarthritis, provides patients with alternatives to invasive surgery. Bone Marrow Stem Cell Therapy has been shown to improve joint function and reduce pain and inflammation. Read more about how this works.

Bone marrow derived stem cells

Bone marrow contains nutrient rich cells to enhance healing process.
Mesenchymal stem cells are able to differentiate into the type of cell in their surrounding environment to replace damaged ones.
MSCs also coordinate healing through a process called "signaling." Cell signaling is the body's way of communicating to coordinate our innate repair system.
MSCs regulate the immune system and healing response by attracting cells to areas where they are most needed.

Leader in Orthobiologic Treatment for Musculoskeletal Conditions

Minotti

Dr. Minotti began performing Orthobiologic Therapy in 2007 and has treated hundreds of patients with amazing success. 86% of his patients have found significant relief from pain and restoration of musculoskeletal function.

Dr. Minotti is specialty trained in Neuromusculoskeletal Medicine. He combines his intensive training in the musculoskeletal system with advanced training in Regenerative Medicine, specifically as applied to orthopedic conditions. He conferences regularly with the world's leading physicians to provide his patients with the most effective treatments that science has to offer.

Founder of North Texas Musculoskeletal Medicine in Southlake TX, Dr. Minotti believes that orthobiologic procedures, such as Platelet Rich Plasma (PRP) and Stem Cell Therapy, are a new frontier in medicine, offering treatments that effectively bridge the gap between medications that mask pain and invasive surgery. He has helped thousands of patients find freedom from pain to restore their quality of life. Dr. Minotti is honored to be recognized by his peers with the Top Docs award. He also serves as an adjunct professor at University of North Texas Health Science Center.

Patient Reviews

Dr. Minotti is brilliant. I was due to schedule rotator cuff surgery. He was able to heal my shoulder. No surgery and no downtime. Recently I had an angry wrist and Dr. Minotti was able to heal it quickly. They are amazing!!!! Autumn Cundiff
Excellent experience! The staff and Dr. Minotti are all friendly, helpful, and knowledgeable. I received PRP Therapy in both knees and have noticed significant improvement in daily movement and functionality. Highly recommend. Charity C
I'm writing this review on behalf of my mom who is a patient here. She raves about Dr. Philip. She had gone in for frozen shoulder and back pain, and is currently undergoing OMT (osteopathic manipulative therapy). After a few treatments, she experienced significant improvements, and she attributes them to “Dr. Philips magic hands”. Not only is he kind and intelligent, but it is very evident that he genuinely cares about his patients. Bottom line: I would highly recommend Dr. R Philip. Maryam
Dr. Minotti is a miracle worker, besides being a very kind and humble doctor. After receiving my PRP treatment one year ago by him and healing for a few months, my back pain has regressed to what it was 10 years ago, which is pretty much nothing!! So not only did he fix my current problem, with his advice, my back is even stronger now. I don't even give walking or standing for hours a second thought these days. Just prior to my PRP treatment, sometimes I couldn't walk for more than 5 minutes without my sciatica pain causing me to sit or bend down to get relief. I was scared of most chairs as well. I can't say enough good things about Dr. Minotti, as well as his wonderful and patient staff!! Susie Shankwitz
Dr. Philip's work in OMT has not only helped to relieve neck pain I had dealt with for years, it is obvious he truly cares for the well-being of his patients through his careful listening and willingness to offer recommendations and guidance. Jennifer F
Dr Minotti and staff have been helping my patients for years with regenerative medicine therapy. All have had a fabulous experience, I guess fate had it that it was finally my turn. 10 years ago I had a knee injury that I never sought attention for - young, broke, ignorant I just kept on keeping on. Well, a few weeks back it finally said enough is enough. After my consultation, I got an MRI and we had a discussion about the best procedure to help my knee heal. I just completed my first treatment with him, and while tender in some areas, I have hope for the first time in years that my knee might actually get back to being normal. Thank you Dr Minotti and staff for being an incredible team. I am blessed beyond measure with the service you provide. Joey Kramer
No more pain, 10000% recommend Dr. Philips. David B
Significant difference in my strength after the treatment!! I wasn't sure how much difference the prp could make, but I thought worth a try. I would have been pleased with half the improvement I received. I'm amazed at the difference 8 weeks after treatment. Dr Minotti is more like a super smart brother, that answers questions in a friendly manner, the way only experts can!Michele I
Dr. Philip has been awesome in helping me heal through several different joint issues. He is very kind and has a great bedside manner as well as being thorough and knowing his stuff! Highly recommend! Kim L
I had struggled with pain in my shoulder as well as low back, hip/sacral area for several years before meeting Dr. Minotti.I had spent quite a bit of time, enegy and financial resources on visits with other doctorsand chiropractors before meeting the team at North Texas Musculoskeletal. I consider myself to be a pretty active inliidual and was very disappointed that I was having to refrain from many types of activities that I enjoyed because the pain was so limiting. It even got to a point where picking up my infant was nearly impossible at times. After treatment with PRP, I was able to slowly ease back into normal exercises and activities that I had missed. I have such high regards for Dr. Minotti and recommend PRP to many that are suffering from pain and would like a more natural approach where our own body can do as it was designed and help heal itself.Charity B.
Dr Philip and then NTXMSK team are awesome. From the initial evaluation and follow up my foot pain was resolved. A therapeutic approach that works. Joseph DAmore
Significant difference in my strength after the treatment!! I wasn't sure how much difference the prp could make, but I thought worth a try. I would have been pleased with half the improvement I received. I'm amazed at the difference 8 weeks after treatment. Dr Minotti is more like a super smart brother, that answers questions in a friendly manner, the way only experts can! Michele I
I am so grateful for Dr. Minotti and his staff! After 10 years of dealing with a painful musculoskeletal injury, Dr. Minotti‘s prolotherapy has made an incredible difference in my life. His skill in how he administers treatment is wonderful — gentle, effective, and always making it as comfortable as possible. Thank you, NTXMSK! Anna F
I have had shoulder pain for 10+ years and was recently told that I'd need a complete shoulder replacement. A friend recommended that I see Dr Minotti before doing any surgery. Thankfully, I did. Dr Minotti did PRP on my right shoulder 8 weeks ago. The whole thing only took about an hour and was relatively painless(a few injections). My shoulder feels better than it has in 10 years. I still have a small amount of pain but NOTHING like before the PRP. He also said that it will continue to get better for another month or so. I couldn't be happier with the results and I would HIGHLY recommend anyone see him if you're having joint pain. Dr Minotti is a lifesaver for me!Rick T
Dr. Philip is seriously amazing! I came in with ongoing back pain I had since almost 10 years ago that just wouldn't go away. It got worse ever since I had my baby but after working with him, I finally got real relief. His OMM skills are on a whole different level. He was super gentle but effective, and I left the appointment feeling so much better than I had in a long time. You can tell he genuinely cares about helping his patients heal, not just treating the symptoms. I'm so thankful I found him and would recommend him to anyone dealing with pain or tension. I feel like a completely different person when I walked out of the clinic and I'm so excited to go back next month! Esther B
Dr Minotti answered my questions in a way that easy to understand. The procedure went exactly as described and the results are excellent. My knee is pain free for the first time in a long time.Lance G
I cannot say enough positive things about this provider. After nearly 16 years of chronic pain due to a stress fracture that rubbed on my Achilles tendon, I finally found relief! ONE treatment of Platelet Rich Plasma solved this issue.Regenerative Orthopedics should be the best practice standard!! Thank you, Dr. Minotti!Teresa C
They are wonderful! They have helped my daughter so much with numerous soccer injuries, both knee and back. Highly recommend! Leah
Best experience I have had with any physician. Not only did he listen , but he took steps to positively address my issues.
ABSOLUTELY the very best in his field. A God send to me. Dr. Minotti has helped me more than any other physician I have consulted with regarding my pain level.

Regenexx is a world-wide network of select, highly skilled physicians who are specially trained in interventional procedures for orthopedic conditions. Regenexx provides the world's most advanced, research-driven, regenerative orthopedic procedures in North America, Europe, the Middle East, Asia and Australia. Specializing in advanced non-surgical procedures for joint Injuries, osteoarthritis, and other orthopedic conditions, Dr. Minotti brings these procedures to you!

To determine if Regenerative Orthopedics will be helpful for you, please tell us about your condition.

Regenerative Information Packet

Common Applications

Numerous conditions can be considered for PRP. Based on current research and clinical experience, moderate to severe cases of osteoarthritis and tendon injuries show promising results.

Knee Pain – Osteoarthritis, Meniscus Tears, Chondromalacia Patella, Tendon Injuries, Ligament sprains or tears.
Hip Pain – Osteoarthritis, Hip Labrum Tears, SI Joint Arthritis, Gluteal tendon tears, Iliotibial Band (ITB) Syndrome
Shoulder – Osteoarthritis, Rotator Cuff Tendinitis, Tendinopathy, or Tears, Labrum Tear, Bicipital Tendinitis
Elbow Pain – Lateral Epicondylitis (Tennis Elbow), Medial Epicondylitis (Golfers Elbow), Osteoarthritis
Wrist/Hand Pain – Osteoarthritis, DeQuervain's Tenosynovitis
Ankle & Foot Pain – Achilles Tendinitis or Partial Tears, Plantar Fasciitis Ankle sprains/ligament injury

Procedure Snapshot

First, a local anesthetic is applied to numb the area of extraction. The bone marrow is extracted from the back of the patient's pelvis or hip bone using a special needle developed for bone marrow extraction. The collected marrow is filtered and spun in a centrifuge to separate the platelets and stem cells to produce the bone marrow aspirate concentrate (BMAC).

The cells are not altered with additives or manipulated. The BMAC is then injected back into the patient's site of injury guided by ultrasound where it can begin its accelerated regenerative healing. This same-day treatment takes about 1-2 hours. Typically, 1 treatment, often with platelet-rich plasma given at follow-up, is sufficient.

FDA APPROVAL

Scientific advances in the understanding of how the body actually heals through tissue regeneration, combined with rapid developments in stem cell biology, have truly created a renaissance in medical treatment. Stem cells, like other medical products that are intended to treat, cure or prevent disease, require U.S. Food and Drug Administration (FDA) approval before they can be marketed. At this time, only cells harvested from the patient's own body and that are only minimally manipulated have been approved by the FDA.

Additionally, devices that allow physicians to minimally manipulate blood, bone marrow and adipose tissue for the treatment of orthopedic conditions also require FDA approval. NTXMSK recognizes and welcomes the FDA's important role in assuring patient safety. All of our treatment protocols are compliant with the published FDA guidelines regarding the use of human cells, tissues, and cellular or tissue-based products.

We can help!

To learn more about what we can do to help with your condition, call our office at 817-416-0970. We will thoroughly diagnose your condition and present you with treatment options. From there we will guide you along your road to recovery.