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What is stem cell therapy

What are stem cells?

The presence of stem cells is key in stimulating the body's natural repair system by inducing the proliferation of cells. Research that examines the biological mechanisms of cellular health and tissue regeneration is extensive, particularly the role of platelets, stem cells and natural growth factors in the blood and bone marrow. Stem cells are present in all of us, acting as a repair system for the body. Mesenchymal stem cells (MSCs) have two primary functions: differentiation into functional cells such as cartilage and coordination of the healing process. 

How does Stem Cell Therapy work?

Stem cell therapy is a non-invasive treatment designed to help the body repair damaged cells. With increased age or chronic injury, often the optimal amount of stem cells is not available. Injury, arthritis and poor cellular health disrupt the availability of stem cells needed for tissue repair resulting in the body's inability to keep pace with healing requirements. When this demand outpaces the supply, the body needs a little help. The potential to treat conditions, such as osteoarthritis, provides patients with alternatives to invasive surgery. Bone Marrow Stem Cell Therapy has been shown to improve joint function and reduce pain and inflammation 

Bone marrow derived stem cells

Nutrient rich cells, including mesenchymal stem cells, in adult bone marrow are extracted from the back of the patient's pelvis or hip bone using a special needle developed for bone marrow extraction. FDA-approved devices concentrate the bone marrow into what is called “Bone Marrow Aspirate Concentrate” (BMAC). This aspirate is then injected through ultrasound guidance directly damaged tissue. 

Mesenchymal stem cells (MSCs) are able to differentiate into the type of cell in their surrounding environment to replace damaged ones. They also coordinate healing through a process called "signaling." Cell signaling is the body's way of communicating in real time to coordinate our innate repair system. Through this system of cellular communication, MSCs regulate the immune system and healing response by attracting cells to areas where they are most needed. Recently, scientists have estimated that 80% of the therapeutic effect of MSCs is attributed to their release of proteins that signal cells to migrate to site of injury to help with cellular repair.

Read more about how this works.


Patient Reviews

  • Johann Weigold

    2 years ago

    6 months ago, I could barely walk or sleep at night due to pain in my left knee. Dr. Minotti and his staff were great to work with and the results have been amazing.

  • Debora Young

    1 year ago

    My knee pain is almost gone and after 7 months. I have noticed increased strength and range of motion when doing yoga. I am VERY grateful for Doctor Minotti & staff.

  • Lance Giles

    1 year ago

    Dr Minotti answered my questions in a way that easy to understand. The procedure went exactly as described and the results are excellent. My knee is pain free for the first time in a long time.

  • Connie Moulder

    1 year ago

    Dr Minotti took care of my torn meniscus with PRP.

  • Wendy Herman

    3 years ago

    Dr. Minotti is simply the best in the business. His needle technique is unparalleled, and is ALWAYS on the cutting edge with his continuing education.

  • Joel Spieth

    1 year ago

    I‘ve seen Dr. Minotti for 7 years. Recently, he helped with knee arthritis treatments that helped me avoid surgery.

  • Rob F.


    After multiple consultations with several different providers, I heard through a colleague about NTMSK and Dr. Minotti. After my initial visit, I'm sure glad I was referred to NTMSK! Before leaving the office, I knew I was in the right place! I've been under the care of Dr. Minotti for the last 8 months and always look forward to the follow up visits. My shoulder is much better than when I initially saw Dr. Minotti in the latter part of 2019. Thank you NTMSK and Dr. Minotti!

  • Rachel L.


    Dr. Minotti is very caring and knowledgeable. We're blessed to have a leader in this field in the DFW metroplex! I'm so happy to be out of pain, back to full strength and to have avoided surgery that would have been costly and would have had long downtime. His staff is great too--no bruising after my blood draw which I greatly appreciated. I highly recommend Dr. Minotti.

  • Jim Mayher


    I felt that I had tried everything, from massage and chiropractic, to acupuncture and even Cervical epidural steroid injection (which were VERY expensive, painful, and even traumatizing); and nothing seemed to work. Then, my Orthopedist told me about Dr. Minotti … WOW! The lessening of pain was amazing and fast – I soon cut back on my medications, and have since eliminated them altogether. The increase in range of motion and mobility, combined with the significant decrease in pain, are phenomenal. I now recommend Dr. Minotti to everyone I know who is suffering from any kind of joint or muscle pain.

  • Sandra L.


    I was a chiropractor junkie. The more I went the more I needed it. I have spondylolisthesis meaning L5 has slipped forward causing me pain and discomfort in my low back and hips. After the first treatment I was 80 percent better and able to resume normal activities. I decided to have a second treatment because I wanted to get to start working out without aggravating my low back. This has truly been life changing and I recommend it to everyone. I have not been to a chiropractor in over 9 months!

Leader in orthobiologic treatment for musculoskeletal conditions


Dr. Minotti began performing Orthobiologic Therapy in 2007 and has treated hundreds of patients with amazing success. 86% of his patients have found significant relief from pain and restoration of musculoskeletal function.

Dr. Minotti is specialty trained in Neuromusculoskeletal Medicine. He combines his intensive training in the musculoskeletal system with advanced training in Regenerative Medicine, specifically as applied to orthopedic conditions. He conferences regularly with the world’s leading physicians to provide his patients with the most effective treatments that science has to offer.

Founder of North Texas Musculoskeletal Medicine in Southlake TX, Dr. Minotti believes that orthobiologic procedures, such as Platelet Rich Plasma (PRP) and Stem Cell Therapy, are a new frontier in medicine, offering treatments that effectively bridge the gap between medications that mask pain and invasive surgery. He has helped thousands of patients find freedom from pain to restore their quality of life. Dr. Minotti is honored to be recognized by his peers with the Top Docs award. He also serves as an adjunct professor at University of North Texas Health Science Center.


Regenexx is a world-wide network of select, highly skilled physicians who are specially trained in interventional procedures for orthopedic conditions. Regenexx provides the world's most advanced, research-driven, regenerative orthopedic procedures in North America, Europe, the Middle East, Asia and Australia. Specializing in advanced non-surgical procedures for joint Injuries, osteoarthritis, and other orthopedic conditions, Dr. Minotti brings these procedures to you!

Stem Cells video

If you have an injury, or if you have tendons or ligaments that have become inflamed, stem cell therapy may help. It uses your body's own stem cells to help heal damage. It may help you avoid surgery.

To determine if Regenerative Orthopedics will be helpful for you, please tell us about your condition.


Procedure SnapshotProcedure Snapshot

First, a local anesthetic is applied to numb the area of extraction. The bone marrow is extracted from the back of the patient's pelvis or hip bone using a special needle developed for bone marrow extraction. The collected marrow is filtered and spun in a centrifuge to separate the platelets and stem cells to produce the bone marrow aspirate concentrate (BMAC).

The cells are not altered with additives or manipulated. The BMAC is then injected back into the patient's site of injury guided by ultrasound where it can begin its accelerated regenerative healing. This same-day treatment takes about 1-2 hours. Typically, 1 treatment, often with platelet-rich plasma given at follow-up, is sufficient.


Scientific advances in the understanding of how the body actually heals through tissue regeneration, combined with rapid developments in stem cell biology, have truly created a renaissance in medical treatment. Stem cells, like other medical products that are intended to treat, cure or prevent disease, require U.S. Food and Drug Administration (FDA) approval before they can be marketed. At this time, only cells harvested from the patient’s own body and that are only minimally manipulated have been approved by the FDA.

Additionally, devices that allow physicians to minimally manipulate blood, bone marrow and adipose tissue for the treatment of orthopedic conditions also require FDA approval. NTXMSK recognizes and welcomes the FDA’s important role in assuring patient safety. All of our treatment protocols are compliant with the published FDA guidelines regarding the use of human cells, tissues, and cellular or tissue-based products.


We Can Help

To learn more about what we can do to help with your condition, call our office at 817-416-0970. We will thoroughly diagnose your condition and present you with treatment options. From there we will guide you along your road to recovery.